Elevated 1,25-dihydroxyvitamin D plasma levels in normal human pregnancy and lactation.
نویسندگان
چکیده
Plasma 1,25-dihydroxyvitamin D levels are elevated in early pregnancy and continue to increase throughout pregnancy. They remain elevated postpartum in lactating women. The elevated levels probably represent a physiological response to increased calcium requirements.
منابع مشابه
Pregnancy does not alter the metabolic clearance of 1,25-dihydroxyvitamin D in rats.
Increased circulating levels of 1,25-dihydroxyvitamin D [1,25(OH)2D] during pregnancy could be due to an increase in production or decrease in the metabolic clearance rate of 1,25(OH)2D. To answer this question an isotope dilution method was used to determine the clearance rate of 1,25(OH)2D in pregnant and aged-matched nonpregnant female rats. A bolus of 0.146 muCi 1,25(OH)2[3H]D3 was given to...
متن کاملSerum 1,25-dihydroxyvitamin D and calcium intake affect rates of bone calcium deposition during pregnancy and the early postpartum period.
BACKGROUND Factors affecting bone calcium deposition across pregnancy and lactation are not well characterized. OBJECTIVE The impact of maternal age, calcium intake, race-ethnicity, and vitamin D status on the rate of bone calcium deposition (VO+) was assessed across pregnancy and lactation. DESIGN Stable calcium isotopes were given to 46 women at pre- or early pregnancy (trimester 1), late...
متن کاملPike, John Wesley 1,25-dihydroxyvitamin D: Hormonal Regulation of Biosynthesis and Purification of Its Intestinal Receptor
The renal biosynthesis of 1,25-dihydroxyvitamin D (l,25-(OH)2B) is known to be stringently regulated by extensive ionic and hormonal controls. Quantitation of this mineral regulating hormone by radio receptor assay has recently enabled a study of its influence and syn thetic control during physiological states of growth and reproduction. The data reveal that 1,25-(0H)̂ D is strikingly elevated...
متن کاملDirect evidence for a causative role of FGF23 in the abnormal renal phosphate handling and vitamin D metabolism in rats with early-stage chronic kidney disease.
Circulating levels of fibroblast growth factor 23 (FGF23) are elevated in patients with early chronic kidney disease (CKD) and are postulated to cause low blood levels of 1,25-dihydroxyvitamin D, as well as normal phosphate levels. In order to provide more direct evidence for the pathophysiological role of FGF23 in the settings of mineral ion homeostasis typically seen in early CKD, we studied ...
متن کاملBone mineralization in the first year of life in infants fed human milk, cow-milk formula, or soy-based formula.
OBJECTIVE To test the hypotheses that (1) bone mineral content (BMC) is similar in infants fed soy-based formula (SBF) and human milk (HM) and higher in infants fed cow milk-based formula (CBF) and (2) serum 1,25-dihydroxyvitamin D, an index of mineral sufficiency, is similar in infants fed formula and infants fed HM. DESIGN Randomized, prospective study of formula-fed group only. SETTING R...
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ورودعنوان ژورنال:
- The Journal of clinical investigation
دوره 63 2 شماره
صفحات -
تاریخ انتشار 1979